Alvira Lab in the department of pediatrics

Members of the Alvira Lab

Cristina M. Alvira, MD
Principal Investigator [calvira]
Phone: 650-723-7297

Academic Appointments
Assistant Professor of Pediatrics, Division of Critical Care Medicine
Associate Program Director of Research: PCCM Fellowship Program

Fellowship: Stanford University School of Medicine, Critical Care Medicine (2005)
Residency: Stanford University School of Medicine, Pediatrics (2002)
Doctor of Medicine: Tufts University School of Medicine (1999)
Bachelor of Science: Tufts University (1999)

Honors and Awards:
AJP-Lung Outstanding Junior Investigator (2013)
American Heart Association Fellow to Faculty Transition Award (2008)
Pediatric Clerkship Honor Roll for Teaching (2007)
Society of Pediatric Research Travel Award (2004)
Western Society for Clinical Investigation Travel Award (2004)
Louise Weinstein Prize for Excellence in Clinical Medicine (1999)
Alpha Omega Alpha National Honor Society (1998)

Dr. Alvira completed her medical school training at Tufts University School of Medicine in Boston. She came to Palo Alto to pursue residency training in pediatrics, and remained at Stanford to pursue subspecialty training in pediatric critical care medicine. During her clinical fellowship, she began working in the laboratory of Dr. Marlene Rabinovitch, a world leader in pulmonary vascular biology. It was during this time within Dr. Rabinovitch’s lab that Dr. Alvira recognized her passion for science in general and NFκB in particular, and continued to pursue extensive post-doctoral training in basic research after the completion of her clinical fellowship in 2005. Dr. Alvira transitioned to her own research program in 2008, and was appointed to the pediatric faculty at Stanford University School of Medicine in 2010. Despite her Spanish heritage, and much to her father’s dismay, she loves all things French, especially French wine. When she is not in the lab, or in her office writing papers and grants, she can be found chasing after her adorable, but extremely mischievous children, cooking, or discovering new Indie bands in San Francisco.


Past Members of the Alvira Lab

Chihhsin Chen, MS
Life Science Research Professional [chench]
Phone: 650-725-1060

After completing the graduate trainings in the east coast, Chihhsin decided to relocate to California to enjoy the sunshine. He joined the Alvira’s lab in 2008 and began to explore the molecular pathways that direct postnatal lung development. In addition to the routine bench work, Chihhsin also heleds to manage the lab in accordance with the government/university regulations. Chihhsin currently works as an LSRP and lab manager of Dr. David Cornfield's lab within the Center for Excellence in Pulmonary Biology.


Yanli joined the laboratory of Dr. Alvira at Stanford in 2010 to study NFκB signaling in lung development. She explored the unique role that NFκB plays in protecting neonatal mice against LPS induced disruption of alveolarization. After completing this porject she remined at Stanford and is currently working on a project using next generation sequencing in cancer patients. She can be found at 1291 Welch Road, R224.


Cristiana Iosef, DVM, PhD

Dr Cristiana Iosef Husted joined the Alvira Laboratory at the Center for Excellence in Pulmonary Biology on May, 2010. By training, Dr Iosef is a cell-biologist able to analyze how factors in the micro-environment impact the molecular signaling and epigenetic profile of developing tissues. Her favorite research tool is molecular imaging. Dr Iosef started her research career in 1989 as a Doctor of Veterinary Medicine at the Institute Pasteur of Bucharest, Romania. During her doctoral studies, Dr Iosef was a Fulbright Scholar at the Washington University School of Medicine in St Louis, MO, under the mentorship of Dr L. Ratner. By extensive post-doctoral training, she specialized in animal models for pediatric diseases (The Ohio State University) and Biochemistry (The University of Western Ontario, Canada). For eight years (2002-2010), Dr Iosef worked as a Research Associate Scientist and co-principal investigator for Dr Victor Han, at the Children's Health Research Institute in Canada where she successfully developed projects which debate the potential epigenetic role of Insulin-like Growth Factors in tissue development and the associated signal transduction events. Cristiana's main focus in the Alvira Laboratory was to define the specific roles that the two NFκB activating kinases, IKKα and IKKβ play in the pulmonary endothelial cells, with a particular interest in understanding how the NFκB pathway influences endothelial development. Currently she works as an Assisstant Professor at The University of Nevada in Reno and she continues to collaborate with our group. When she is not in the lab, Cristiana can be found in karate class (watch out!), sailing, painting, and hiking.

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