Alvira Lab in the department of pediatrics
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Endothelial Cell Homeostasis

Transcription factors controlling survival, proliferation, and angiogenesis

Alveolarization

Molecular mechanisms controlling the final stage of lung development

Ontogeny of the Pulmonary Circulation

Factors controlling endothelial cell fate

Endothelial Cell Migration

Pathways promoting pulmonary angiogenesis

Alvira Lab

Alvira Lab Overview

Alveolarization, the final stage of lung development, begins just before birth and extends into young adulthood. It is this process of alveolarization that results in the formation of the pulmonary capillary network, and the 20-fold expansion of lung surface airway, both essential for air-breathing life. Disruption of this process in infants contributes to the development of numerous forms of pediatric lung disease, including congenital alveolar dysplasia, lung hypoplasia, and bronchopulmonary dysplasia. The overall objective of the Alvira Laboratory is to elucidate the molecular mechanisms that direct alveolar development. To this end, the lab is currently focused on three fundamental scientific goals: (i) identification of the signaling pathways that allow for the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury.

 

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